Milbemite

Dosage Form: FOR ANIMAL USE ONLY
Milbemite Otic Solution

Milbemite™ OTIC Solution

(0.1% milbemycin oxime)

Caution:

U.S. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description:

Milbemite OTIC Solution is available in plastic dispensing tubes with break-off tips. Each plastic tube contains 0.25 mL of Milbemite OTIC Solution as a 0.1% solution of milbemycin oxime. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A4 (C32H45NO7, MW 555.71) and 20% A3 (C31H43NO7, MW 541.68).

Indications:

Milbemite OTIC Solution is indicated for treatment of ear mite (Otodectes cynotis) infestations in cats and kittens four weeks of age and older. Effectiveness is maintained throughout the life cycle of the ear mite.

Human Warnings:

Not for human use. Keep this and all drugs out of the reach of children.

Precautions:

The safe use of Milbemite OTIC Solution in cats used for breeding purposes, during pregnancy, or in lactating queens, has not been evaluated.

Adverse Reactions:

No adverse reactions caused by Milbemite OTIC Solution have been reported in controlled effectiveness studies in adult cats and kittens (4 weeks of age).

Dosage:

 Milbemite OTIC Solution should be administered topically into the external ear canal as the entire contents of a single-dose tube per ear. The volume delivered will be approximately 0.2 mL, with 0.05 mL residual volume remaining in dispensing tube. Repeat the treatment one time if necessary, based upon the ear mite life cycle and the response to treatment.

Administration:

Milbemite OTIC Solution should be administered as one tube per ear as a single treatment. Each foil pouch contains two tubes of solution, one for each ear. Open the tube by snapping off the cap. Squeeze the tube to administer the contents of one tube into each external ear canal. Massage the base of the ear for optimal distribution. In clinical field trials, ears were not cleaned and many animals still had debris in their ears at the end of the study. Cleaning of the external ear canal prior to treatment may be performed, but is not necessary to provide effectiveness.

Effectiveness:

The clinical effectiveness of milbemycin oxime 0.1% solution was evaluated in a placebo-controlled clinical field trial of client-owned cats. Otodectes cynotis infestation was diagnosed by direct microscopic visualization of ear swab debris. Test or placebo treatment was administered to both ears of the cat following the pre-treatment examination. Cats’ ears were examined by ear swab microscopy at multiple intervals throughout the life cycle of the mite (up to day 30). Ninety-nine percent (99%) of the milbemycin oxime-treated group were ear mite negative at the microscopic exams.

Safety:

A study was conducted using otic doses of 0.1, 0.3 or 0.5% milbemycin oxime solutions administered once weekly for six applications in kittens that were 4 weeks of age at the initiation of the study. Otic doses of 0.1 and 0.3% did not produce adverse systemic or local effects. One kitten treated with 0.5% was lethargic 8 hours after the second treatment. The kitten was offered milk replacer and by 10 hours post-treatment it appeared normal. In this kitten, lethargy was not observed after subsequent treatments. A study was conducted to evaluate the safety of a 0.1% milbemycin oxime solution in adult cats. Topical doses at 1X, 3X or 5X the recommended dose applied in one ear did not produce adverse effects.

Storage Conditions:

 Milbemite OTIC Solution should be stored at room temperature, between 59° and 77° F (15-25° C).

How Supplied:

Milbemite OTIC Solution is supplied in individual white polypropylene tubes, paired in a foil overlay pouch. The product is packaged in a box of 10 pouches of 2 tubes of 0.25 mL each.

U.S. Patent No. 4,547,520

Manufactured for: Novartis Animal Health US, Inc.

Greensboro, NC 27408 USA

NADA #141-163, Approved by FDA.

©2002 Novartis

NAH/MIL-LE/VI/3

PRINCIPAL DISPLAY PANEL

MilbemiteTM 

OTIC Solution (0.1% milbemycin oxime)

FOR USE IN

CATS & KITTENS

FOUR WEEKS

OF AGE

AND OLDER

Net contents:

10 pouches of

2 tubes of

0.25 mL each

NADA # 141-163, Approved by the FDA.

Milbemite  milbemycin oxime  solution

Product Information Product Type PRESCRIPTION ANIMAL DRUG NDC Product Code (Source) 58198-8602 Route of Administration AURICULAR (OTIC) DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength MILBEMYCIN OXIME (MILBEMYCIN OXIME) MILBEMYCIN OXIME 1 mg  in 1 mL

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 58198-8602-5 10 POUCH In 1 BOX contains a POUCH 1 2 TUBE In 1 POUCH This package is contained within the BOX (58198-8602-5) and contains a TUBE 1 0.25 mL In 1 TUBE This package is contained within a POUCH and a BOX (58198-8602-5)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NADA	NADA141163	02/02/2000

Labeler - Novartis Animal Health US, Inc. (966985624)

Revised: 03/2010Novartis Animal Health US, Inc.

Monopril

Generic Name: fosinopril (Oral route)

fos-IN-oh-pril

Oral route(Tablet)

ACE inhibitors can cause injury or death to the developing fetus when used during the second and third trimesters. Stop therapy as soon as possible when pregnancy is detected .

Commonly used brand name(s)

In the U.S.

• Monopril

Available Dosage Forms:

• Tablet

Therapeutic Class: Antihypertensive

Pharmacologic Class: ACE Inhibitor

Uses For Monopril

Fosinopril is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Fosinopril works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax. This lowers blood pressure and increases the supply of blood and oxygen to the heart .

In addition, fosinopril is used to treat congestive heart failure or may be used for other conditions as determined by your doctor .

This medicine is available only with your doctor's prescription .

Before Using Monopril

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of fosinopril in children with hypertension who are 6 to 16 years of age. Safety and efficacy have not been established in children who are 5 years old and younger .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of fosinopril in the elderly. However, elderly patients are more likely to have age-related kidney or heart problems, which may require an adjustment of dose in patients receiving fosinopril .

Pregnancy

	Pregnancy Category	Explanation
1st Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
3rd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alteplase, Recombinant


• Amiloride


• Azathioprine


• Canrenoate


• Eplerenone


• Potassium


• Spironolactone


• Triamterene

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aceclofenac


• Acemetacin


• Alclofenac


• Aliskiren


• Apazone


• Azosemide


• Bemetizide


• Bendroflumethiazide


• Benoxaprofen


• Benzthiazide


• Bromfenac


• Bufexamac


• Bumetanide


• Bupivacaine


• Buthiazide


• Capsaicin


• Carprofen


• Chlorothiazide


• Chlorthalidone


• Clometacin


• Clonixin


• Clopamide


• Cyclopenthiazide


• Cyclothiazide


• Dexketoprofen


• Diclofenac


• Diflunisal


• Dipyrone


• Droxicam


• Ethacrynic Acid


• Etodolac


• Etofenamate


• Felbinac


• Fenbufen


• Fenoprofen


• Fentiazac


• Floctafenine


• Flufenamic Acid


• Flurbiprofen


• Furosemide


• Gold Sodium Thiomalate


• Hydrochlorothiazide


• Hydroflumethiazide


• Ibuprofen


• Indapamide


• Indomethacin


• Indoprofen


• Isoxicam


• Ketoprofen


• Ketorolac


• Lithium


• Lornoxicam


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Methyclothiazide


• Metolazone


• Nabumetone


• Naproxen


• Nesiritide


• Niflumic Acid


• Nimesulide


• Oxaprozin


• Oxyphenbutazone


• Phenylbutazone


• Pirazolac


• Piretanide


• Piroxicam


• Pirprofen


• Polythiazide


• Propyphenazone


• Proquazone


• Quinethazone


• Sulindac


• Suprofen


• Tenidap


• Tenoxicam


• Tiaprofenic Acid


• Tolmetin


• Torsemide


• Trichlormethiazide


• Xipamide


• Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angioedema, history of—This medicine may increase the risk of this condition occurring again .

• Dehydration or


• Diarrhea or


• Heart failure or


• Hyponatremia (low sodium in the blood) or


• Kidney disease—These conditions may cause the blood pressure to fall too low with fosinopril .

• Liver disease—The effects of fosinopril may be increased because of slower removal from the body .

Proper Use of Monopril

In addition to the use of fosinopril, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For high blood pressure:
    
    • Adults—At first, 10 milligrams (mg) once a day. Then, your doctor may increase your dose to 20 to 40 mg per day taken as a single dose or divided into two doses. Some patients may need up to 80 mg per day.
    
    
    • Children 6 years of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 5 to 10 mg once a day in children weighing over 50 kilograms (kg) or 110 pounds (lb).
    
    
    • Children under 6 years of age—Use and dose must be determined by your doctor .
    
    
  
  
  • For heart failure:
    
    • Adults—At first, 10 milligrams (mg) once a day. Then, your doctor may increase your dose to 20 to 40 mg per day taken as a single dose.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Monopril

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects .

Stop using this medicine and call your doctor right away if you have swelling of the face, arms, legs, eyes, lips, or tongue, or problems with swallowing or breathing. These are symptoms of a condition called angioedema .

Stop using this medicine and call your doctor right away if you have severe stomach pain. This could be a symptom of a condition called intestinal angioedema .

You may experience lightheadedness during the first few days with this medicine. If this becomes severe and you faint, stop using this medicine and talk to your doctor right away .

Tell your doctor immediately if you have any signs of infection such as chills, sore throat, or fever. These may be symptoms of an immune system condition called neutropenia .

If your symptoms do not improve within a few days or if they become worse, check with your doctor .

Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away .

Check with your doctor right away if you have symptoms of jaundice (yellow skin or eyes) because these may be signs of a serious liver condition .

This medicine may increase the amount of potassium in your blood. Do not use salt substitutes containing potassium without first checking with your doctor .

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests .

Monopril Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Blurred vision


• chest pain or discomfort


• chills


• cold sweats


• confusion


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• fast, slow, or irregular heartbeat


• pounding or rapid pulse


• sweating


• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Cough

Less common

• Body aches or pain


• diarrhea


• difficult breathing


• ear congestion


• fever


• headache


• loss of voice


• muscle or bone pain


• nasal congestion


• nausea and vomiting


• runny nose


• sneezing


• sore throat


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Monopril side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Monopril resources

• Monopril Side Effects (in more detail)
• Monopril Dosage
• Monopril Use in Pregnancy & Breastfeeding
• Drug Images
• Monopril Drug Interactions
• Monopril Support Group
• 1 Review for Monopril - Add your own review/rating

• Monopril Prescribing Information (FDA)


• Monopril Consumer Overview


• Monopril Monograph (AHFS DI)


• Monopril MedFacts Consumer Leaflet (Wolters Kluwer)


• Fosinopril Prescribing Information (FDA)

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Minoxidil Foam (For Men)

Pronunciation: min-OX-i-dil
Generic Name: Minoxidil
Brand Name: Rogaine

Minoxidil Foam (For Men) is used for:

Regrowing hair in patients who have gradually thinning hair or gradual hair loss on the top of the head.

Minoxidil Foam (For Men) is a vasodilator. Exactly how Minoxidil Foam (For Men) works to regrow scalp hair is not known. It may dilate blood vessels in the scalp. This may improve hair follicle function and stimulate scalp hair growth.

Do NOT use Minoxidil Foam (For Men) if:

• you are allergic to any ingredient in Minoxidil Foam (For Men)


• you are a woman


• you only have hair loss toward the front of your head (eg, a receding hair line); Minoxidil Foam (For Men) is not used to treat this kind of hair loss


• you have no family history of hair loss or you do not know the reason for your hair loss


• you have sudden or patchy hair loss


• your scalp is red, inflamed, infected, or painful


• you are using other medicines on your scalp

Contact your doctor or health care provider right away if any of these apply to you.

Before using Minoxidil Foam (For Men):

Some medical conditions may interact with Minoxidil Foam (For Men). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart, blood pressure, or blood vessel problems

Some MEDICINES MAY INTERACT with Minoxidil Foam (For Men). Because little, if any, of Minoxidil Foam (For Men) is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Minoxidil Foam (For Men) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Minoxidil Foam (For Men):

Use Minoxidil Foam (For Men) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Minoxidil Foam (For Men) comes with an extra patient leaflet. Talk to your pharmacist if you have questions about this information.


• Apply half a capful to the area of hair loss as directed.


• Do NOT apply to red, irritated, or inflamed skin.


• Minoxidil Foam (For Men) is only for use on the top of the head. Do NOT apply to other parts of the body.


• Wash your hands after using Minoxidil Foam (For Men).


• Use Minoxidil Foam (For Men) on a regular schedule to get the most benefit from it. Continue to use Minoxidil Foam (For Men) even when your hair begins to grow. Do not miss any doses.


• If you miss a dose of Minoxidil Foam (For Men), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Minoxidil Foam (For Men).

Important safety information:

• Minoxidil Foam (For Men) may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Minoxidil Foam (For Men) with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Minoxidil Foam (For Men) is for topical use only. Avoid getting Minoxidil Foam (For Men) in your eyes, nose, or mouth. If you get Minoxidil Foam (For Men) in your eyes, wash them out with cool tap water.


• It may take 2 to 4 months for Minoxidil Foam (For Men) to work. If you do not see hair regrowth after 4 months, check with your doctor.


• If you stop using Minoxidil Foam (For Men) regularly, you may lose the hair that has regrown. Your hair loss may begin again.


• Do NOT use more than the recommended dose or use more often than directed without checking with your doctor.


• Minoxidil Foam (For Men) may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• Minoxidil Foam (For Men) is extremely flammable. Do not get near fire or a flame. Do not smoke while using or right after using Minoxidil Foam (For Men).


• Talk with your doctor before you use any other medicines on your scalp.


• Minoxidil Foam (For Men) should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Minoxidil Foam (For Men) may cause harm to the fetus. It is not known if Minoxidil Foam (For Men) is found in breast milk. Minoxidil Foam (For Men) should not be used by women.

Possible side effects of Minoxidil Foam (For Men):

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in hair color or texture.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dizziness; fainting; fast heartbeat; redness or irritation of the scalp; sudden, unexplained weight gain; swelling of the hands or feet; unwanted facial hair growth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Minoxidil Foam (For Men) may be harmful if swallowed.

Proper storage of Minoxidil Foam (For Men):

Store Minoxidil Foam (For Men) at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a tightly closed container. Store away from heat and direct sunlight. Do not store above 120 degrees F (49 degrees C). Do not puncture, break, or burn the canister even if it appears to be empty. Keep Minoxidil Foam (For Men) out of the reach of children and away from pets.

General information:

• If you have any questions about Minoxidil Foam (For Men), please talk with your doctor, pharmacist, or other health care provider.


• Minoxidil Foam (For Men) is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Minoxidil Foam (For Men). If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Minoxidil Foam (For Men) resources

• Minoxidil Foam (For Men) Use in Pregnancy & Breastfeeding
• Minoxidil Foam (For Men) Drug Interactions
• Minoxidil Foam (For Men) Support Group
• 7 Reviews for Minoxidil (For Men) - Add your own review/rating

Compare Minoxidil Foam (For Men) with other medications

• Alopecia

emtricitabine

em-trye-SYE-ta-been

Oral route(Capsule;Solution)

Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination with other antiretrovirals. Emtricitabine is not approved for the treatment of chronic hepatitis B virus (HBV) infection and the safety and efficacy have not been established in patients co-infected with HBV and HIV. Severe acute exacerbations of hepatitis B have been reported in patients who have discontinued emtricitabine; monitor hepatic function upon discontinuation of therapy .

Commonly used brand name(s)

In the U.S.

• Emtriva

Available Dosage Forms:

• Capsule


• Solution

Therapeutic Class: Antiretroviral Agent

Pharmacologic Class: Nucleoside Reverse Transcriptase Inhibitor

Uses For emtricitabine

Emtricitabine is used together with other medicines to treat human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS).

HIV infection destroys CD4 (T) cells, which are important to the immune system in your body. The immune system helps fight infection. After a large number of T cells are destroyed, acquired immune deficiency syndrome (AIDS) develops.

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI). It blocks HIV reverse transcriptase, a chemical in your body (enzyme) that is needed for HIV to multiply. emtricitabine may lower the amount of HIV in your blood (viral load). It may also help to increase the number of T cells, also called CD4 cells. Lowering the amount of HIV in your blood lowers the chance of having problems when your immune system is weak.

Emtricitabine will not cure or prevent HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.

Emtricitabine will not keep you or your child from spreading HIV to other people. People who receive emtricitabine may continue to have the problems usually related to AIDS or HIV disease.

emtricitabine is available only with your doctor's prescription.

Before Using emtricitabine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For emtricitabine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to emtricitabine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of emtricitabine in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of emtricitabine in the elderly. However, elderly patients are more likely to have age-related heart, kidney, or liver problems which may require an adjustment of dose in patients receiving emtricitabine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of emtricitabine. Make sure you tell your doctor if you have any other medical problems, especially:

• Hepatitis B virus (HBV) infection—Emtricitabine is not used to treat patients with hepatitis B virus infection. You or your child may receive emtricitabine to treat HIV infection even if you also have hepatitis B virus infection. Your doctor will want to follow you closely for several months once you stop taking emtricitabine.

• Kidney disease—Use with caution. Emtricitabine may be removed more slowly from the body.

Proper Use of emtricitabine

Take emtricitabine exactly as directed by your doctor. Do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking emtricitabine without checking with your doctor first.

It is important to take emtricitabine together in combination with other HIV medicines. Take all other medicines your doctor prescribed at the right time of the day. This will make your medicines work better.

When your emtricitabine supply runs low, get more from your pharmacy or from your doctor. The amount of virus in your blood may increase if the medicine is stopped, even for a short time. The virus may develop resistance to emtricitabine and be harder to treat.

emtricitabine can be taken with or without food.

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

emtricitabine comes with patient instructions. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. You should talk to your doctor if you have any questions.

Dosing

The dose of emtricitabine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of emtricitabine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For treatment of HIV infection:
  
  • For oral dosage form (capsules):
    
    • Adults—200 milligrams (mg) once a day.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor.
    
    
  
  
  • For oral dosage form (solution):
    
    • Adults—240 milligrams (mg) or 24 milliliters (mL) once a day.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of emtricitabine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the capsules in a closed container at room temperature, away from heat, moisture, and direct light.

Store the oral solution in the refrigerator if possible. Do not freeze. If the solution must be stored at room temperature, throw away any unused medicine after 3 months.

Precautions While Using emtricitabine

It is very important that your doctor check your progress at regular visits to make sure that emtricitabine is working properly. Blood tests may be needed to check for unwanted effects. Also, you or your child should remain under the care of a doctor while taking emtricitabine.

You or your child should not use emtricitabine if you are also taking lamivudine, Atripla™, Combivir®, Epivir®, Epivir-HBV®, Epzicom®, Trizivir®, or Truvada®. Tell your doctor right away if you are using any of these medicines. Do not start using emtricitabine until your doctor tells you to.

Two rare but serious reactions to emtricitabine are lactic acidosis (too much acid in the blood) and liver toxicity, which includes an enlarged liver. These are more common if you are female, very overweight (obese), or have been taking anti-HIV medicines for a long time. Call your doctor right away if you or your child have more than one of these symptoms: abdominal discomfort or cramping; dark urine; decreased appetite; diarrhea; general feeling of discomfort; light-colored stools; muscle cramping or pain; nausea; unusual tiredness or weakness; trouble breathing; vomiting; or yellow eyes or skin.

emtricitabine may cause you or your child to have excess body fat. Tell your doctor right away if you notice changes in your body shape, including an increased amount of body fat in the neck or upper back, face, around the chest, or stomach area. You might also lose fat from your legs, arms, or face.

When you or your child start taking HIV medicines, your immune system may get stronger. If you have infections that are hidden in your body (e.g., pneumonia or tuberculosis), you may notice new symptoms when your body tries to fight them. If this occurs, tell your doctor right away.

You should not breastfeed if you have HIV or AIDS, because you may give the infection to your baby through your breast milk.

Emtricitabine does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contamination through blood. HIV may be spread to others through infected body fluids, including blood, vaginal fluid, or semen. If you are infected, it is best to avoid any sexual activity involving an exchange of body fluids with other people. If you do have sex, always wear (or have your partner wear) a condom (“rubber”). Only use condoms made of latex or polyurethane and use them every time you have contact with semen, vaginal secretions, or blood. Also, do not share needles with anyone or use dirty needles. If you have any questions about this, check with your doctor.

emtricitabine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Burning, crawling, itching, numbness, prickling, "pins and needles”, or tingling feelings


• chest pain


• cough or hoarseness


• fever or chills


• lower back or side pain


• painful or difficult urination


• pale skin


• shortness of breath


• sneezing


• sore throat


• tightness in chest


• troubled breathing with exertion


• unusual bleeding or bruising


• unusual tiredness or weakness


• wheezing

Less common

• Sensation of pins and needles


• stabbing pain

Incidence unknown

• Abdominal discomfort


• decreased appetite


• diarrhea


• fast, shallow breathing


• general feeling of discomfort


• muscle pain or cramping


• nausea


• sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal pain


• abnormal dreams


• acid or sour stomach


• belching


• darkening of skin


• depression problems


• difficulty swallowing


• dizziness


• earache


• headache


• heartburn


• hives or welts


• indigestion


• itching skin


• lack or loss of strength


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• rash with flat lesions or small raised lesions on the skin


• redness of skin


• redness or swelling in ear


• runny nose


• spots on your skin resembling a blister or pimple


• stuffy nose


• vomiting

Less common

• Difficulty in moving


• joint pain


• muscle stiffness


• sleeplessness


• swollen joints


• trouble sleeping


• unable to sleep


• unsteadiness or awkwardness


• weakness in arms, hands, legs, or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: emtricitabine side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More emtricitabine resources

• Emtricitabine Side Effects (in more detail)
• Emtricitabine Use in Pregnancy & Breastfeeding
• Emtricitabine Drug Interactions
• Emtricitabine Support Group
• 0 Reviews for Emtricitabine - Add your own review/rating

• Emtricitabine Professional Patient Advice (Wolters Kluwer)


• Emtricitabine Monograph (AHFS DI)


• Emtricitabine MedFacts Consumer Leaflet (Wolters Kluwer)


• Emtriva Prescribing Information (FDA)


• Emtriva Consumer Overview

Compare emtricitabine with other medications

• HIV Infection
• Nonoccupational Exposure

Mononine injectable

Generic Name: factor IX complex (injectable) (FAC tor NINE)

Brand Names: Alphanine SD, Bebulin VH, Benefix, Konyne 80, Mononine, Profilnine SD, Proplex T

What is factor IX complex?

Factor IX is a natural protein, normally present in the blood, that helps blood to clot. A lack of this protein causes hemophilia B (Christmas disease). Factor IX complex also contains small amounts of other blood clotting factors.

Factor IX complex is used to treat or prevent bleeding in people with hemophilia B. Some forms of factor IX complex may also be used to treat or prevent bleeding in people with factor VII deficiency or inhibitors to factor VIII.

Factor IX complex may also be used for purposes other than those listed here.

What is the most important information I should know about factor IX complex?

Factor IX complex is made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although factor IX complex is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using factor IX complex.

Some viruses, such as parovovirus B19 and hepatitis A, may be more difficult to identify or remove from factor IX complex. Parovovirus B19 may more seriously affect pregnant women and those with poor immune systems. Symptoms of parovovirus B19 infection include fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain. Symptoms of hepatitis A may include several days to weeks of poor appetite, tiredness, and low-grade fever followed by nausea, vomiting, and pain in the belly. Dark-colored urine and yellowing of the skin or whites of the eyes may also occur. Contact your doctor if you develop any of these symptoms after treatment with factor IX complex.

Carry or wear identification that will alert others that you have hemophilia or another blood clotting disorder in the case of an emergency.

Tell your doctor and dentist that you have hemophilia or another blood clotting disorder before having surgery or other invasive procedures.

What should I discuss with my healthcare provider before using factor IX complex?

Do not use factor IX complex without first talking to your doctor if you have

• had an unusual or allergic reaction to this medication, a similar medication, a human or animal (mouse or hamster) protein, dyes, additives, or preservatives;


• hardening of the arteries;


• 
  

  severe injury or infection;

  
  


• liver disease; or


• 
  

  other bleeding or blood clotting disorders.

  
  

You may not be able to use factor IX complex or you may require a dosage adjustment or special monitoring during treatment.

Factor IX complex is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not use factor IX complex without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether factor IX complex could be harmful to a nursing baby. Do not use factor IX complex without first talking to your doctor if you are breast-feeding a baby.

How should I use factor IX complex?

Factor IX complex will be administered by intravenous (into a vein) injection by a healthcare provider.

Your doctor may want you to have blood tests or other medical evaluations during treatment with factor IX to monitor progress and side effects.

Carry or wear identification that will alert others that you have hemophilia or another blood clotting disorder in the case of an emergency.

Your healthcare provider will store factor IX complex as directed by the manufacturer.

If you are using factor IX complex at home, your doctor or healthcare provider will give you detailed instructions on how to administer and store the medication.

What happens if I miss a dose?

Contact your doctor if a dose of factor IX is missed.

What happens if I overdose?

Seek emergency medical attention if an overdose of factor IX complex is suspected.

What should I avoid while using factor IX complex?

Tell your doctor and dentist that you have hemophilia or another blood clotting disorder before having surgery or other invasive procedures.

Factor IX complex side effects

Factor IX complex is made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although factor IX complex is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using factor IX complex.

Some viruses, such as parovovirus B19 and hepatitis A, may be more difficult to identify or remove from factor IX complex. Parovovirus B19 may more seriously affect pregnant women and those with poor immune systems. Symptoms of parovovirus B19 infection include fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain. Symptoms of hepatitis A may include several days to weeks of poor appetite, tiredness, and low-grade fever followed by nausea, vomiting, and pain in the belly. Dark-colored urine and yellowing of the skin or whites of the eyes may also occur. Contact your doctor if you develop any of these symptoms after treatment with factor IX complex.

If you experience any of the following serious side effects, contact your healthcare provider immediately or seek emergency medical attention:

• 
  

  an allergic reaction (shortness of breath; wheezing; tightness of the chest; closing of the throat; hives; swelling of the lips, face, or tongue; hives or rash; dizziness or fainting); or

  
  


• 
  

  fever;

  
  


• 
  

  nausea or vomiting;

  
  


• 
  

  increased heart rate;

  
  


• 
  

  decreased blood pressure (may result in dizziness or fainting);

  
  


• 
  

  difficulty breathing, chest pain, or cough; or

  
  


• 
  

  pain, redness, or swelling at the injection site.

  
  

Other, less serious side effects may be more likely to occur. Continue to use factor IX complex and talk to your doctor if you experience

• 
  

  headache; or

  
  


• 
  

  flushing.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect factor IX complex?

Other drugs that affect bleeding or blood-clotting processes can interact with factor IX complex resulting in dangerous side effects and/or altered effectiveness. Do not take any other prescription or over-the-counter medicines, including herbal products, without first talking to your doctor during treatment with factor IX complex.

Where can I get more information?

• Your pharmacist has additional information about factor IX complex written for health professionals that you may read.

What does my medication look like?

Factor IX complex is available with a prescription under the several brand names. Generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Mapap Suppositories

Pronunciation: a-SEET-a-MIN-oh-fen
Generic Name: Acetaminophen
Brand Name: Examples include Mapap and Tylenol

Mapap Suppositories are used for:

Treating minor aches and pains due to headache, muscle aches, backache, arthritis, the common cold, the flu, toothache, menstrual cramps, and immunizations, and for temporarily reducing fever.

Mapap Suppositories are an analgesic and antipyretic (lowers fever). It works by lowering a chemical in the brain that stimulates pain nerves and the heat-regulating center in the brain.

Do NOT use Mapap Suppositories if:

• you are allergic to any ingredient in Mapap Suppositories

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mapap Suppositories:

Some medical conditions may interact with Mapap Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of alcohol abuse or you drink more than 3 alcohol-containing drinks every day


• if you have liver or kidney problems

Some MEDICINES MAY INTERACT with Mapap Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Isoniazid because the risk of liver problems may be increased


• Anticoagulants (eg, warfarin) because the risk of their side effects, including bleeding, may be increased by Mapap Suppositories

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mapap Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mapap Suppositories:

Use Mapap Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wash your hands before and after using Mapap Suppositories. If the suppository is too soft to use, put it in the refrigerator for about 15 minutes. You may also run cold water over it. Remove the wrapper. Moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum. Use your finger to push it in completely.


• If you miss a dose of Mapap Suppositories and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Mapap Suppositories.

Important safety information:

• Mapap Suppositories has acetaminophen in it. Before you start any new medicine, check the label to see if it has acetaminophen in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Mapap Suppositories may harm your liver. Your risk may be greater if you drink alcohol while you are using Mapap Suppositories. Talk to your doctor before you take Mapap Suppositories or other fever reducers if you drink more than 3 drinks with alcohol per day.


• Severe or persistent sore throat or sore throat accompanied by high fever, headache, nausea, and vomiting may be serious. Consult a doctor promptly. Do not use for more than 2 days or give to CHILDREN younger than 3 years old unless directed by a doctor.


• Mapap Suppositories may cause the results of some in-home test kits for blood cholesterol to be wrong. Check with your doctor or pharmacist if you are taking Mapap Suppositories and need to check your blood cholesterol at home.


• Do NOT use more than the dose recommended by your doctor or on the package labeling. If you use more of Mapap Suppositories than recommended, the risk of severe liver damage may be increased. Check with your doctor or pharmacist if you are not sure how much of Mapap Suppositories may be used.


• For pain and fever in CHILDREN: Stop use and ask a doctor if fever gets worse or lasts more than 3 days, pain gets worse or lasts more than 5 days, or redness or swelling is present or any new symptoms appear.


• For pain and fever in ADULTS: Stop use of Mapap Suppositories and ask your doctor if pain gets worse or lasts more than 10 days, fever gets worse or lasts more than 3 days, new symptoms occur, or redness or swelling is present.


• PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Mapap Suppositories while you are pregnant. Mapap Suppositories are found in breast milk. If you are or will be breast-feeding while you use Mapap Suppositories, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Mapap Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine or pale stools; stomach pain; unusual fatigue; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Mapap side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dark urine; excessive sweating, extreme fatigue; nausea and vomiting; stomach pain.

Proper storage of Mapap Suppositories:

Store Mapap Suppositories at room temperature, between 35 and 80 degrees F (2 and 27 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Mapap Suppositories out of the reach of children and away from pets.

General information:

• If you have any questions about Mapap Suppositories, please talk with your doctor, pharmacist, or other health care provider.


• Mapap Suppositories are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Mapap Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Mapap resources

• Mapap Side Effects (in more detail)
• Mapap Use in Pregnancy & Breastfeeding
• Drug Images
• Mapap Drug Interactions
• Mapap Support Group
• 0 Reviews for Mapap - Add your own review/rating

Compare Mapap with other medications

• Fever
• Muscle Pain
• Pain
• Sciatica

Migquin

Generic Name: isometheptene, dichloralphenazone, and acetaminophen (Oral route)

eye-soe-meth-EP-teen MUE-kate, dye-klor-al-FEN-a-zone, a-seet-a-MIN-oh-fen

Commonly used brand name(s)

In the U.S.

• Amidrine


• Diacetazone


• Duradrin


• Epidrin


• Iso-Acetazone


• Midrin


• Migquin


• Migratine


• Migrazone


• Migrin-A


• Nodolor


• Va-Zone

Available Dosage Forms:

• Capsule

Therapeutic Class: Acetaminophen Combination

Pharmacologic Class: Isometheptene

Uses For Migquin

Isometheptene, dichloralphenazone, and acetaminophen combination is used to treat certain kinds of headaches, such as “tension” headaches and migraine headaches. This combination is not used regularly (for example, every day) to prevent headaches. It should be taken only after headache pain begins, or after a warning sign that a migraine is coming appears. Isometheptene helps to relieve throbbing headaches, but it is not an ordinary pain reliever. Dichloralphenazone helps you to relax, and acetaminophen relieves pain.

This medicine is available only with your doctor's prescription.

Before Using Migquin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies with this medicine have been done only in adult patients, and there is no specific information about its use in children.

Geriatric

Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this combination medicine in the elderly with use in other age groups.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Clorgyline


• Iproniazid


• Isocarboxazid


• Moclobemide


• Nialamide


• Pargyline


• Phenelzine


• Procarbazine


• Selegiline


• Toloxatone


• Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Bromocriptine


• Fospropofol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Carbamazepine


• Isoniazid


• Phenytoin


• Warfarin


• Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Cabbage

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse or


• Heart attack (recent) or


• Heart or blood vessel disease or


• Kidney disease or


• Liver disease or


• Stroke (recent) or


• Virus infection of the liver (viral hepatitis)—The chance of side effects may be increased

• Glaucoma, not well controlled, or


• High blood pressure (hypertension), not well controlled—The isometheptene in this combination medicine may make these conditions worse

Proper Use of isometheptene, dichloralphenazone, and acetaminophen

This section provides information on the proper use of a number of products that contain isometheptene, dichloralphenazone, and acetaminophen. It may not be specific to Migquin. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often than directed, and do not take it every day for several days in a row. If the amount you are to take does not relieve your headache, check with your doctor. If a headache medicine is used too often, it may lose its effectiveness or even cause a type of physical dependence. If this occurs, your headaches may actually get worse. Also, taking too much acetaminophen can cause liver damage.

This medicine works best if you:

• Take it as soon as the headache begins. If you get warning signals of a migraine, take this medicine as soon as you are sure that the migraine is coming. This may even stop the headache pain from occurring.


• Lie down in a quiet, dark room until you are feeling better.

People who get a lot of headaches may need to take a different medicine to help prevent headaches. It is important that you follow your doctor's directions, even if your headaches continue to occur. Headache-preventing medicines may take several weeks to start working. Even after they do start working, your headaches may not go away completely. However, your headaches should occur less often, and they should be less severe and easier to relieve, than before. This will reduce the amount of headache relievers that you need. If you do not notice any improvement after several weeks of headache-preventing treatment, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For “tension” headaches:
  
  • Adults: 1 or 2 capsules every 4 hours, as needed. Not more than 8 capsules a day.
  
  
  • Children: Dose must be determined by the doctor.
  
  


• For migraine headaches:
  
  • Adults: 2 capsules for the first dose, then 1 capsule every hour, as needed. Not more than 5 capsules in 12 hours.
  
  
  • Children: Dose must be determined by the doctor.
  
  

Precautions While Using Migquin

Check with your doctor:

• If the medicine stops working as well as it did when you first started using it. This may mean that you are in danger of becoming dependent on the medicine. Do not try to get better relief by increasing the dose.


• If you are having headaches more often than you did before you started using this medicine. This is especially important if a new headache occurs within 1 day after you took your last dose of headache medicine, headaches begin to occur every day, or a headache continues for several days in a row. This may mean that you are dependent on the medicine. Continuing to take this medicine will cause even more headaches later on. Your doctor can give you advice on how to relieve the headaches.

Check the labels of all nonprescription (over-the-counter [OTC]) and prescription medicines you now take. Taking other medicines that contain acetaminophen together with this medicine may lead to an overdose. If you have any questions about this, check with your health care professional.

This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally. These effects may be especially severe if you also take CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness) together with this medicine. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; antiemetics (medicines that prevent or relieve nausea or vomiting), and anesthetics. If you are not able to lie down for a while, make sure you know how you react to this medicine or combination of medicines before you drive, use machines, or do anything else that could be dangerous if you are drowsy or dizzy or are not alert.

Do not drink alcoholic beverages while taking this medicine. To do so may increase the chance of liver damage caused by acetaminophen, especially if you drink large amounts of alcoholic beverages regularly. Also, because drinking alcoholic beverages may make your headaches worse or cause new headaches to occur, people who often get headaches should probably avoid alcohol.

Migquin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

• Unusual tiredness or weakness

Rare

• Black, tarry stools


• blood in urine or stools


• pinpoint red spots on skin


• skin rash, hives, or itching


• sore throat and fever


• unusual bleeding or bruising


• yellow eyes or skin

Symptoms of dependence on this medicine

• Headaches, more severe and/or more frequent than before

Symptoms of acetaminophen overdose

• Diarrhea


• increased sweating


• loss of appetite


• nausea or vomiting


• pain, tenderness, and/or swelling in the upper abdominal (stomach) area


• stomach cramps or pain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness

Rare

• Dizziness


• fast or irregular heartbeat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Migquin side effects (in more detail)

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More Migquin resources

• Migquin Side Effects (in more detail)
• Migquin Use in Pregnancy & Breastfeeding
• Migquin Drug Interactions
• Migquin Support Group
• 1 Review for Migquin - Add your own review/rating

• Migquin Concise Consumer Information (Cerner Multum)


• Duradrin MedFacts Consumer Leaflet (Wolters Kluwer)

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