Menostar

Generic Name: estradiol transdermal (ess tra DYE ol tranz DERM al)

Brand Names: Alora, Climara, Estraderm, Estradiol Patch, Menostar, Vivelle, Vivelle-Dot

What is estradiol transdermal?

Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the body.

Estradiol transdermal skin patches are used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. Estradiol transdermal also reduces urgency or irritation of urination.

Estradiol skin patches are also used to treat ovarian disorders, infertility, and abnormal vaginal bleeding. Some estradiol skin patches are used to prevent postmenopausal osteoporosis. Transdermal skin patches release the drug slowly, and it is absorbed through your skin.

Estradiol transdermal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about estradiol transdermal?

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a bleeding disorder, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding. This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol transdermal.

Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol transdermal.

The estradiol transdermal patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test.

What should I discuss with my healthcare provider before using estradiol transdermal?

Do not use estradiol transdermal if you have:

• 
  

  a bleeding or blood-clotting disorder;

  
  


• 
  

  a history of stroke or circulation problems;

  
  


• 
  

  abnormal vaginal bleeding that a doctor has not checked; or

  
  


• 
  

  any type of breast, uterine, or hormone-dependent cancer.

  
  

To make sure you can safely use estradiol transdermal, tell your doctor if you have any of these other conditions:

• 
  

  high blood pressure, angina, or heart disease;

  
  


• 
  

  high cholesterol or triglycerides;

  
  


• liver disease;


• kidney disease;


• 
  

  asthma;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  migraines;

  
  


• 
  

  diabetes;

  
  


• 
  

  depression;

  
  


• 
  

  gallbladder disease; or

  
  


• 
  

  if you have had your uterus removed (hysterectomy).

  
  

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol transdermal.

Long-term estradiol treatment may increase your risk of stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

FDA pregnancy category X. This medication can cause birth defects. Do not use estradiol transdermal if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.

How should I use estradiol transdermal?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Apply the skin patch to clean, dry skin on your stomach, lower back, or buttocks. Choose a different spot within these skin areas each time you apply a new patch. Avoid skin that is oily, irritated, or damaged.

Press the patch in place firmly for about 10 seconds, especially around the edges.

Do not apply a skin patch to your breasts. Do not apply a patch where it might be rubbed off by tight clothing, such as under an elastic waistband.

If a patch falls off, try putting it back on to a different skin area, pressing the patch into place for 10 seconds. If the patch will not stick you may apply a new one.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol transdermal.

The estradiol transdermal patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply a skin patch as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra patches to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What should I avoid while using estradiol transdermal?

Avoid using other estrogen products without your doctor's advice.

Grapefruit and grapefruit juice may interact with estradiol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Estradiol transdermal side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  
  


• 
  

  sudden numbness or weakness, especially on one side of the body;

  
  


• 
  

  sudden severe headache, confusion, problems with vision, speech, or balance;

  
  


• 
  

  pain or swelling in your lower leg;

  
  


• 
  

  abnormal vaginal bleeding;

  
  


• 
  

  pain, swelling, or tenderness in your stomach;

  
  


• 
  

  jaundice (yellowing of the skin or eyes); or

  
  


• 
  

  a lump in your breast.

  
  

Less serious side effects may include:

• 
  

  nausea, vomiting, loss of appetite;

  
  


• 
  

  swollen breasts;

  
  


• 
  

  acne or skin color changes;

  
  


• 
  

  decreased sex drive, impotence, or difficulty having an orgasm;

  
  


• 
  

  migraine headaches or dizziness;

  
  


• 
  

  vaginal pain, dryness, or discomfort;

  
  


• 
  

  swelling of your ankles or feet;

  
  


• 
  

  depression; or

  
  


• 
  

  changes in your menstrual periods, break-through bleeding.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect estradiol transdermal?

Tell your doctor about all other medicines you use, especially:

• 
  

  carbamazepine (Carbatrol, Equetro, Tegretol);

  
  


• 
  

  phenobarbital (Luminal, Solfoton);

  
  


• 
  

  St. John's wort;

  
  


• 
  

  a blood thinner such as warfarin (Coumadin, Jantoven);

  
  


• 
  

  an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifampin (Rifadin, Rifater, Rifamate, Rimactane), or telithromycin (Ketek);

  
  


• 
  

  antifungal medication such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend); or

  
  


• 
  

  ritonavir (Norvir, Kaletra) and other HIV/AIDS medications.

  
  

This list is not complete and other drugs may interact with estradiol transdermal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Menostar resources

• Menostar Side Effects (in more detail)
• Menostar Use in Pregnancy & Breastfeeding
• Menostar Drug Interactions
• Menostar Support Group
• 0 Reviews for Menostar - Add your own review/rating

• Menostar Advanced Consumer (Micromedex) - Includes Dosage Information


• Menostar Weekly Patch MedFacts Consumer Leaflet (Wolters Kluwer)


• Menostar Prescribing Information (FDA)


• Menostar Consumer Overview


• Estradiol Professional Patient Advice (Wolters Kluwer)


• Estradiol Prescribing Information (FDA)


• Estradiol MedFacts Consumer Leaflet (Wolters Kluwer)


• Estradiol Monograph (AHFS DI)


• estradiol Transdermal Advanced Consumer (Micromedex) - Includes Dosage Information


• Alora Prescribing Information (FDA)


• Climara Weekly Patch MedFacts Consumer Leaflet (Wolters Kluwer)


• Climara Prescribing Information (FDA)


• Climara Consumer Overview


• Delestrogen MedFacts Consumer Leaflet (Wolters Kluwer)


• Delestrogen Prescribing Information (FDA)


• Depo-Estradiol Prescribing Information (FDA)


• Depo-Estradiol MedFacts Consumer Leaflet (Wolters Kluwer)


• Estrace Consumer Overview


• Estrace Prescribing Information (FDA)


• Estrace MedFacts Consumer Leaflet (Wolters Kluwer)


• Estrace Advanced Consumer (Micromedex) - Includes Dosage Information


• Estraderm Patch MedFacts Consumer Leaflet (Wolters Kluwer)


• Estraderm Prescribing Information (FDA)


• Estradiol Patch Prescribing Information (FDA)


• Estrasorb Prescribing Information (FDA)


• Estrasorb Emulsion MedFacts Consumer Leaflet (Wolters Kluwer)


• Estrasorb Consumer Overview


• Evamist Prescribing Information (FDA)


• Evamist Consumer Overview


• Evamist Spray MedFacts Consumer Leaflet (Wolters Kluwer)


• Femring Ring MedFacts Consumer Leaflet (Wolters Kluwer)


• Femring Prescribing Information (FDA)


• Femtrace MedFacts Consumer Leaflet (Wolters Kluwer)


• Femtrace Consumer Overview


• Femtrace Prescribing Information (FDA)


• Femtrace Advanced Consumer (Micromedex) - Includes Dosage Information


• Vivelle Prescribing Information (FDA)


• Vivelle-Dot Prescribing Information (FDA)

Compare Menostar with other medications

• Osteoporosis

Where can I get more information?

• Your pharmacist can provide more information about estradiol transdermal.

See also: Menostar side effects (in more detail)

Colcrys

Generic Name: colchicine (KOL chi seen)

Brand Names: Colcrys

What is colchicine?

Colchicine affects the way the body responds to uric acid crystals, which reduces swelling and pain.

Because colchicine was developed prior to federal regulations requiring FDA review of all marketed drug products, not all uses for colchicine have been approved by the FDA. As of 2009, Colcrys is the only brand of colchicine that has been approved by the FDA.

The Colcrys brand of colchicine is FDA-approved to treat gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who are at least 4 years old.

Generic forms of colchicine have been used to treat or prevent attacks of gout, or to treat symptoms of Behcets syndrome (such as swelling, redness, warmth, and pain).

Colchicine is not a cure for gouty arthritis or Behcets syndrome, and it will not prevent these diseases from progressing. Colchicine should not be used as a routine pain medication for other conditions.

Colchicine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about colchicine?

Because colchicine was developed prior to federal regulations requiring FDA review of all marketed drug products, not all uses for colchicine have been approved by the FDA. As of 2009, Colcrys is the only brand of colchicine that has been approved by the FDA. You should not use this medication if you are allergic to colchicine. Do not take colchicine if you have liver or kidney disease and are also taking any of the medications listed below under "What other drugs can affect colchicine."

Before taking colchicine, tell your doctor if yo have liver or kidney disease, heart disease, a stomach ulcer, ulcerative colitis, Crohn's disease, intestinal bleeding, or any other severe gastrointestinal disorder.

If you take colchicine over a long period of time, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Call your doctor at once if you have a serious side effect such as muscle pain or weakness, numbness or tingly feeling in your fingers or toes, severe vomiting or diarrhea, easy bruising or bleeding, feeling weak or tired, flu symptoms, blood in your urine, urinating less than usual or not at all, or a pale or gray appearance of your lips, tongue, or hands.

What should I discuss with my healthcare provider before taking colchicine?

You should not use this medication if you are allergic to colchicine. Do not take colchicine if you have liver or kidney disease and are also taking any of the medications listed below under "What other drugs can affect colchicine."

To make sure you can safely take colchicine, tell your doctor if you have any of these other conditions:

• liver disease;


• kidney disease;


• 
  

  heart disease;

  
  


• 
  

  a stomach ulcer or severe gastrointestinal disorder;

  
  


• 
  

  ulcerative colitis;

  
  


• 
  

  Crohn's disease; or

  
  


• 
  

  intestinal bleeding or other disorder.

  
  

FDA pregnancy category C. It is not known whether colchicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether colchicine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take colchicine?

If your doctor has prescribed the Colcrys brand of colchicine, do not use any other type or brand of the medication. Colcrys is the only brand of colchicine that has been approved by the FDA. If you use a generic brand of colchicine, you may be using an unapproved dose of this medication, which could be dangerous. Do not purchase colchicine on the Internet or from vendors outside of the United States. Using this medication improperly or without the advice of a doctor can result in serious side effects or death.

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Colchicine can be taken with or without food.

To treat a gout attack, for best results take colchicine at the first sign of the attack. The longer you wait to start taking the medication, the less effective it may be.

You may need to take a second lower dose of colchicine 1 hour after the first dose if you still have gout pain. Follow your doctor's instructions.

Your dose will depend on the reason you are taking this medication. Colchicine doses for gout and Mediterranean fever are different.

If you use this medication over a long period of time, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Keep using colchicine as directed, even if you feel well. Tell your doctor if the medicine seems to stop working as well in preventing gout attacks. Do not stop using colchicine without first talking to your doctor.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of colchicine can be fatal.

Overdose symptoms may include diarrhea (may be bloody and severe), nausea, vomiting, stomach pain, heartburn, a burning feeling in your throat or stomach, muscle weakness, urinating less than usual, numbness or tingling, fainting, or seizure (convulsions).

What should I avoid while taking colchicine?

Grapefruit and grapefruit juice may interact with colchicine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Colchicine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  muscle pain or weakness;

  
  


• 
  

  numbness or tingly feeling in your fingers or toes;

  
  


• 
  

  pale or gray appearance of your lips, tongue, or hands;

  
  


• 
  

  severe vomiting or diarrhea;

  
  


• 
  

  easy bruising or bleeding, feeling weak or tired;

  
  


• 
  

  fever, chills, body aches, flu symptoms;

  
  


• 
  

  blood in your urine; or

  
  


• 
  

  urinating less than usual or not at all.

  
  

Less serious side effects may include:

• 
  

  mild nausea or vomiting, stomach pain; or

  
  


• 
  

  mild diarrhea.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect colchicine?

Colchicine can interact with certain other drugs. A colchicine drug interaction can be fatal. Tell your doctor about all other medications you use, especially:

• 
  

  conivaptan (Vaprisol);

  
  


• 
  

  digoxin (Lanoxin, digitalis);

  
  


• 
  

  imatinib (Gleevec);

  
  


• 
  

  isoniazid (for treating tuberculosis);

  
  


• 
  

  an antidepressant such as nefazodone;

  
  


• 
  

  an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);

  
  


• 
  

  antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

  
  


• 
  

  cholesterol-lowering medicines such as atorvastatin (Lipitor), fenofibrate (Antara, Lipofen, TriCor), fluvastatin (Lescol), gemfibrozil (Lopid), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), simvastatin (Zocor, Simcor, Vytorin), and others;

  
  


• 
  

  heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Nifedical, Procardia), quinidine (Quin-G), reserpine, verapamil (Calan, Covera, Isoptin, Verelan), and others;

  
  


• 
  

  HIV or AIDS medication such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), ritonavir (Kaletra, Norvir), tipranavir (Aptivus); or

  
  


• 
  

  medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf).

  
  

This list is not complete and there may be other drugs that can interact with colchicine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Colcrys resources

• Colcrys Side Effects (in more detail)
• Colcrys Use in Pregnancy & Breastfeeding
• Colcrys Drug Interactions
• Colcrys Support Group
• 5 Reviews for Colcrys - Add your own review/rating

• Colcrys Monograph (AHFS DI)


• Colcrys Prescribing Information (FDA)


• Colcrys Consumer Overview


• Colcrys Advanced Consumer (Micromedex) - Includes Dosage Information


• Colcrys MedFacts Consumer Leaflet (Wolters Kluwer)


• Colchicine MedFacts Consumer Leaflet (Wolters Kluwer)


• Colchicine Professional Patient Advice (Wolters Kluwer)

Compare Colcrys with other medications

• Familial Mediterranean Fever
• Gout, Acute
• Gout, Prophylaxis

Where can I get more information?

• Your pharmacist can provide more information about colchicine.

See also: Colcrys side effects (in more detail)

Minocin Injection

Pronunciation: MIN-oh-SYE-kleen
Generic Name: Minocycline
Brand Name: Minocin

Minocin Injection is used for:

Treating infections caused by certain bacteria. It is also used with other medicines to treat severe acne. It may also be used for other conditions as determined by your doctor.

Minocin Injection is a tetracycline antibiotic. It works by slowing the growth of certain bacteria and allowing the body's immune system to destroy them.

Do NOT use Minocin Injection if:

• you are allergic to any ingredient in Minocin Injection or to another tetracycline (eg, doxycycline)


• you are taking acitretin, isotretinoin, a live oral typhoid vaccine, methoxyflurane, or a penicillin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Minocin Injection:

Some medical conditions may interact with Minocin Injection. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have asthma, kidney or liver problems, or an autoimmune disorder (eg, lupus)

Some MEDICINES MAY INTERACT with Minocin Injection. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Acitretin, anticoagulants (eg, warfarin), digoxin, ergot alkaloids and derivatives (eg, ergotamine), insulin, isotretinoin, methotrexate, methoxyflurane , or theophyllines because the risk of their side effects may be increased by Minocin Injection


• Live oral typhoid vaccine, oral contraceptives (birth control pills), or penicillin antibiotics (eg, amoxicillin) because their effectiveness may be decreased by Minocin Injection

This may not be a complete list of all interactions that may occur. Ask your health care provider if Minocin Injection may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Minocin Injection:

Use Minocin Injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Minocin Injection is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Minocin Injection at home, a health care provider will teach you how to use it. Be sure you understand how to use Minocin Injection. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use Minocin Injection if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• To clear up your infection completely, take Minocin Injection for the full course of treatment. Keep taking it even if you feel better in a few days.


• Minocin Injection works best if it is used at the same time each day.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Minocin Injection, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Minocin Injection.

Important safety information:

• Minocin Injection may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Minocin Injection with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Long-term or repeated use of Minocin Injection may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Minocin Injection may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Minocin Injection. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Minocin Injection only works against bacteria; it does not treat viral infections (eg, the common cold).


• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.


• Tell your doctor or dentist that you take Minocin Injection before you receive any medical or dental care, emergency care, or surgery.


• Be sure to use Minocin Injection for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Minocin Injection. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Minocin Injection may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Minocin Injection.


• Lab tests, including kidney function, liver function, and complete blood cell counts, may be performed while you use Minocin Injection. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Minocin Injection with caution in the ELDERLY; they may be more sensitive to its effects.


• Minocin Injection should not be used in CHILDREN younger than 8 years old; safety and effectiveness in these children have not been confirmed. Using Minocin Injection in CHILDREN younger than 8 years old or in women during the last half of pregnancy may cause a permanent change in the tooth coloring of the child.


• PREGNANCY and BREAST-FEEDING: Minocin Injection has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Minocin Injection while you are pregnant. Minocin Injection is found in breast milk. Do not breast-feed while taking Minocin Injection.

Possible side effects of Minocin Injection:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; lightheadedness; loss of appetite; nausea; pain, swelling, or redness at the injection site; sore mouth, throat, or tongue; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; blurred vision; change in the amount of urine produced; decreased hearing; fever, chills, or sore throat; joint pain; muscle pain or weakness; pain, redness, swelling, or white patches in the mouth; red, swollen, blistered, or peeling skin; redness or swelling of the gums; ringing in the ears; seizures; severe diarrhea; severe or persistent headache; severe skin reaction to the sun; shortness of breath or wheezing; stomach cramps or pain; symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; persistent nausea, stomach pain, or loss of appetite); symptoms of pancreatitis (eg, severe stomach or back pain with or without nausea or vomiting); unusual bruising or bleeding; unusual tiredness or weakness; vaginal irritation or discharge.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Minocin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness, nausea, or vomiting.

Proper storage of Minocin Injection:

Minocin Injection is usually handled and stored by a health care provider. If you are using Minocin Injection at home, store Minocin Injection as directed by your pharmacist or health care provider. Keep Minocin Injection out of the reach of children and away from pets.

General information:

• If you have any questions about Minocin Injection, please talk with your doctor, pharmacist, or other health care provider.


• Minocin Injection is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Minocin Injection. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Minocin resources

• Minocin Side Effects (in more detail)
• Minocin Use in Pregnancy & Breastfeeding
• Drug Images
• Minocin Drug Interactions
• Minocin Support Group
• 11 Reviews for Minocin - Add your own review/rating

Compare Minocin with other medications

• Acne
• Actinomycosis
• Bacterial Infection
• Bullous Pemphigoid
• Meningitis, Meningococcal
• Ocular Rosacea
• Pemphigoid
• Pemphigus
• Rosacea
• Skin and Structure Infection
• Skin Infection

Tetracyclic antidepressants

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Tetracyclic antidepressants contain four cyclic rings as part of their structure. Tetracyclic antidepressants are similar to tricyclic antidepressants and act by inhibiting reuptake of neurotransmitters serotonin and/or noradrenaline in the brain, and elevate mood. They are effective antidepressants but are used less often now due to their side effect profile.

See also

Medical conditions associated with tetracyclic antidepressants:

• Anxiety
• Depression
• Hot Flashes
• Insomnia
• Panic Disorder
• Post Traumatic Stress Disorder

Drug List:

Remeron

Ludiomil

Remeron-Soltab-Orally-Disintegrating-Tablets

Menomune

Pronunciation: ma-nin-ja-KOK-al
Generic Name: Meningococcal Vaccine (A, C, Y, W-135)
Brand Name: Menomune

Menomune is used for:

Preventing infection caused by certain types of meningococcal bacteria (eg, meningococcal meningitis).

Menomune is a vaccine. It works by causing your immune system to produce antibodies that help to prevent infection by certain meningococcal bacteria.

Do NOT use Menomune if:

• you are allergic to any ingredient in Menomune, including thimerosal


• you are ill or have an infection


• you are also receiving a whole-cell pertussis or whole-cell typhoid vaccine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Menomune:

Some medical conditions may interact with Menomune. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine (especially those that suppress the immune system), herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances (eg, latex rubber)


• if you have immune system problems or have recently had or are planning to have any other vaccinations

Some MEDICINES MAY INTERACT with Menomune. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Medicines that suppress the immune system such as corticosteroids (eg, prednisone), cancer chemotherapy (eg, methotrexate), or cyclosporine because effectiveness of Menomune may be decreased


• Whole-cell pertussis or whole-cell typhoid vaccine because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Menomune may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Menomune:

Use Menomune as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Menomune is usually administered as an injection at your doctor's office, hospital, or clinic.


• If Menomune contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.


• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.


• If you miss a dose of Menomune, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Menomune.

Important safety information:

• Menomune may not work as well in patients who have immune system problems or are taking medicine that suppresses the immune system, such as corticosteroids (eg, prednisone). Tell your doctor if you have any immune system problems or other illnesses.


• Protective antibody levels may be achieved within 7 to 10 days after vaccination.


• Use Menomune with extreme caution in CHILDREN younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is unknown if Menomune can cause harm to the fetus. If you become pregnant while taking Menomune, discuss with your doctor the benefits and risks of using Menomune during pregnancy. It is unknown if Menomune is excreted in breast milk. If you are or will be breast-feeding while you are using Menomune, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Menomune:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Chills; fever (low grade); headache; tenderness, pain, redness, or swelling at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Menomune side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Menomune:

Menomune is usually handled and stored by a health care provider. If you are using Menomune at home, store Menomune as directed by your pharmacist or health care provider.

General information:

• If you have any questions about Menomune, please talk with your doctor, pharmacist, or other health care provider.


• Menomune is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Menomune. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Menomune resources

• Menomune Side Effects (in more detail)
• Menomune Use in Pregnancy & Breastfeeding
• Menomune Drug Interactions
• Menomune Support Group
• 0 Reviews for Menomune - Add your own review/rating

Compare Menomune with other medications

• Meningococcal Meningitis Prophylaxis

Ephedrine Nasal Drops 1.0%

1. Name Of The Medicinal Product

Ephedrine Nasal Drops 1.0%

2. Qualitative And Quantitative Composition

Ephedrine Hydrochloride BP 1.0% W/V

3. Pharmaceutical Form

Nasal Drops.

4. Clinical Particulars

4.1 Therapeutic Indications

For the relief of nasal congestion.

4.2 Posology And Method Of Administration

Nasal, by application to the mucous membranes.

RECOMMENDED DOSE

Instil one or two drops into each nostril.

DOSAGE SCHEDULE

As required, but not more than 4 times a day.

The above dose and schedule are recommended for adults, the elderly and children over 12 years.

4.3 Contraindications

Ephedrine should not be given to patients who are being treated with monoamine oxidase inhibitors, or within two weeks of stopping such treatment (see section 4.5).

Ephedrine should not be taken with beta-blockers (see section 4.5)

It should be used with caution in patients receiving halogenated anaesthetics.

Ephedrine nasal drops should not be used concomitantly with other sympathomimetic decongestants.

It should also be avoided in patients with cardiovascular disease, cardiac arrhythmias, cardiomyopathy and peripheral vascular disease, hypertension, hyperthyroidism, hyperexcitability, phaeochromocytoma, closed-angle glaucoma and urinary retention.

Ephedrine nasal drops should not be used after nasal or sinus surgery.

Excessive and/or frequent use of a nasal decongestant should be avoided.

Children under 12 years of age.

Hypersensitivity to ephedrine or to any of the excipients.

4.4 Special Warnings And Precautions For Use

Store below 25°C. Do not allow to freeze.

Keep all medicines away from children.

Warning: asthmatics should consult their doctor before using this product.

Ephedrine should be used with care in the elderly and in patients with prostatic hypertrophy, diabetes mellitus or renal impairment.

The product should not be used for longer than 7 days. Avoid contamination during use. Keep away from eyes.

10ml pack label states: do not share the drops with anyone.

10ml pack states: discard any unused drops 2 months after opening.

Do not give to children under 12 years.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Medicinal products, the use of which may be affected by ephedrine nasal drops:

MAOIs: Risk of hypertensive crisis. Sympathomimetics such as ephedrine should not be given with MAOIs or within 14 days of stopping treatment (see Section 4.3).

Anti-arrhythmics - including beta-blockers and quinidine: ephedrine may increase the risk of arrhythmias, and block the hypotensive effects of beta-blockers (see Section 4.3);

Adrenergic neurone blockers (such as guanethidine): ephedrine may block the hypotensive effects.

Cardiac glycosides (such as digoxin or digitoxin), or tricyclic antidepressants: ephedrine may increase the risk of arrythmias.

Ergotamine and methysergide: ephedrine may increase the risk of ergotism.

Oxytocin: there is increased risk of hypertension when vasoconstrictor sympathomimetics are given with oxytocin.

Doxapram: there is increased risk of hypertension when sympathomimetics are given with doxapram.

Dexamethasone: ephedrine accelerates the metabolism of dexamethasone.

MAO-B inhibitors (such as rasagiline and selegiline): risk of hypertension.

Theophylline: concomitant use with ephedrine may potentiate the adverse effects.

Volatile anaesthetics: ephedrine should be avoided in patients undergoing anaesthesia with volatile anaesthetics – risk of hazardous arrhythmias (see Section 4.3).

Thyroid hormones: Caution is required with sympathomimetics and thyroid hormones.

Appetite suppressants and amphetamine-like psychostimulants: risk of hypertension.

Medicinal products potentially affecting the activity of ephedrine:

Antihypertensives such as guanethidine, reserpine and probably methyldopa may diminish the effects of ephedrine.

Tricyclic antidepressants may reduce the effect of sympathomimetics.

Caffeine may enhance the side effects of ephedrine.

Antipsychotics may antagonise the hypertensive effects of sympathomimetics.

4.6 Pregnancy And Lactation

This product should not be used in pregnancy or whilst breast feeding unless recommended by a doctor. Ephedrine crosses the placenta and has been associated with an increase in foetal heart rate. Ephedrine has been reported to cause irritability and disturbed sleep in infants when used during breast feeding.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

The following undesirable effects have been reported following use of ephedrine and may arise following use of ephedrine nasal drops. The frequency of adverse effects cannot be estimated from available data, but adverse effects may be minimised by avoiding prolonged or excessive use (see section 4.4).

Metabolism and nutrition disorders: Hyperglycaemia, hypokalaemia.

Psychiatric disorders: hallucinations, paranoia.

Nervous system disorders: Anxiety, restlessness, irritability, tremors, headache, tolerance, dependence, insomnia, dizziness and fainting.

Eye disorders: Mydriasis.

Cardiac disorders: Palpitations, arryhythmias.

Vascular disorders: Hypertension (vasoconstriction with hypertension), vasodilation with hypotension, flushing, impaired circulation to the extremities.

Respiratory, thoracic and mediastinal disorders: dyspnoea.

Gastrointestinal disorders: Nausea, thirst, dry mouth, anorexia, vomiting, increased salivation.

Skin & subcutaneous tissue disorders: Sweating, dermatitis, piloerection.

Musculoskeletal and connective tissue disorders: Muscular weakness.

Renal and Urinary disorders: Difficulty in micturition in patients with prostatic enlargement, urinary retention.

General disorders and administration site conditions: Local irritation, dryness, pain, rebound congestion and drug-induced rhinitis.

4.9 Overdose

The estimated minimal lethal dose of ephedrine in children up to 2 years of age is 200mg, and for adults 2g, but fatalities due to ephedrine overdose are rare and not likely to occur following administration of the nasal drops. Single doses of up to 400mg of ephedrine have been given without serious toxic effects. In large doses ephedrine may cause giddiness, headache, nausea, vomiting, sweating, thirst, tachycardia, precordial pain, palpitations, difficulty in micturition, muscular weakness and tremors, anxiety, restlessness and insomnia. Paranoid psychosis, delusions, and hallucinations may follow overdosage. Treatment of overdosage should include supportive and symptomatic therapy. In severe cases the stomach should be emptied by aspiration and lavage. Diazepam may be given to control central nervous system stimulation.

Chlorpromazine may be given for excitement or the management of hallucinations. A beta-adrenoceptor blocking agent may be required to control cardiac arrhythmias. Acute poisoning with chlorobutanol is also highly improbable considering the concentration in the drops and the method of administration, however treatment for overdosage would be aspiration and lavage.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Ephedrine hydrochloride is applied locally to relieve congestion of mucous membranes in acute sinusitis and hay fever. It has a stimulant action on the respiratory centre. Ephedrine releases norepinephrine from storage sites in the sympathetic nerves to the effector organ. It exhibits tachyphylaxis; repeated infusions become less effective as the releasable stores of norepinephrine are depleted.

Ephedrine redistributes the blood flow and causes cardiac stimulation, without markedly raising the blood pressure.

Sympathomimetic drugs exert their effect by vasoconstriction of the mucosal blood vessels, which in turn reduces the thickness of the nasal mucosa. However, they can give rise to a rebound phenomenon as their effects wear off, due to a secondary vasodilation with a subsequent temporary increase in nasal congestion.

5.2 Pharmacokinetic Properties

Ephedrine is readily and completely absorbed from the gastro-intestinal tract. It is resistant to metabolism by monoamine oxidase and is largely excreted unchanged in the urine, together with small amounts of metabolites produced by hepatic metabolism. Ephedrine has been variously reported to have a plasma half-life ranging from 3 to 6 hours depending on urinary pH; elimination is enhanced and half-life accordingly shorter in acid urine

5.3 Preclinical Safety Data

No data of relevance, which is additional to that included on other sections of the SPC.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Chlorobutanol BP, Sodium Chloride BP, Purified Water BP.

6.2 Incompatibilities

None known.

6.3 Shelf Life

10 ml: 18 months unopened, 2 months after first opening.

500 ml: 18 months unopened.

6.4 Special Precautions For Storage

Store below 25°C.

6.5 Nature And Contents Of Container

10 ml: amber glass, winchester bottle with 20mm R3 plastic wadded cap.

6.6 Special Precautions For Disposal And Other Handling

None.

7. Marketing Authorisation Holder

Thornton & Ross Ltd

Linthwaite Laboratories,

Huddersfield,

HD7 5QH.

8. Marketing Authorisation Number(S)

PL 00240/ 5006R

9. Date Of First Authorisation/Renewal Of The Authorisation

29.03.90 / 24.06.97

10. Date Of Revision Of The Text

10/01/2011

malathion topical

Generic Name: malathion topical (MAL a THYE on TOP i kal)

Brand Names: Ovide

What is malathion?

Malathion is an anti-parasite medication.

Malathion is used to treat head lice.

Malathion may also be used for purposes not listed in this medication guide.

What is the most important information I should know about malathion?

Avoid getting this medication in your eyes. If this does happen, rinse with water. Do not use this medication on a child younger than 6 years old. Do not allow an older child to use malathion without supervision of an adult.

Malathion lotion is flammable. Do not use this medication near high heat or open flame. Do not use a curling iron, hair dryer, or other heat styler on treated hair. Warn children to stay away from open flames and electric heat sources while the hair is wet.

For the most complete treatment of lice or scabies and to prevent reinfection, you must treat your environment (clothing, bedding, pillows, furniture, hats, hair brushes and accessories, etc) at the same time you treat your scalp.

Avoid sexual or intimate contact with others until your lice or scabies infection has cleared up. Avoid sharing hair brushes, combs, hair accessories, hats, clothing, bed linens, and other articles of personal use. Lice and scabies infections are highly contagious.

What should I discuss with my healthcare provider before using malathion?

You should not use this medication if you are allergic to malathion. FDA pregnancy category B. Malathion topical is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether malathion topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication on a child younger than 6 years old. Do not allow an older child to use malathion without supervision of an adult.

How should I use malathion?

Do not take this medication by mouth. It is for use only on your scalp.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Keep your eyes tightly closed while applying malathion topical.

Use malathion on scalp hair only. Apply to dry hair. Use just enough lotion to wet the hair and scalp, making sure you also cover the back of the head and neck.

Wash your hands after applying the medication.

Allow your hair to air dry and do not cover your head.

Shampoo your hair after 8 to 12 hours, making sure you also wash the back of your head and neck. Rinse hair thoroughly.

While your hair is slightly damp, use a nit comb to remove lice eggs from the hair. Work on only one section of hair at a time, combing through 1- to 2-inch strands from the scalp to the ends.

Rinse the nit comb often during use. Place removed nits into a sealed plastic bag and throw it into the trash to prevent re-infestation. Check the scalp again daily to make sure all nits have been removed.

If you feel severe scalp irritation when applying malathion, wash your hair and scalp right away. You may reapply the medicine at a later time, but if severe irritation occurs again call your doctor.

Malathion lotion is flammable. Do not use this medication near high heat or open flame. Do not use a curling iron, hair dryer, or other heat styler on treated hair. Warn children to stay away from open flames and electric heat sources while the hair is wet.

Do not smoke while applying malathion. Avoid being near a lighted cigarette while your hair is still wet with malathion.

Use a second application of malathion if you still see lice 7 to 9 days after your first treatment. If you still have lice after 2 treatments with malathion topical, call your doctor.

To prevent reinfection, wash all clothing, hats, bed clothes, bed linens, and towels in hot water and dry in high heat. Dry-clean any non-washable clothing. Hair brushes, combs, and hair accessories should be soaked in hot water for at least 10 minutes. For the most complete treatment of lice or scabies and to prevent reinfection, you must treat your environment (clothing, bedding, pillows, furniture, hats, hair brushes and accessories, etc) at the same time you treat your scalp. Store this medicine at room temperature away from moisture, high heat, open flame, or electric heat sources.

What happens if I miss a dose?

Since malathion topical is usually needed only once, you are not likely to be on a dosing schedule. Wait at least 7 days before using a second application.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Malathion topical can be harmful if swallowed.

What should I avoid while using malathion?

Avoid getting this medication in your eyes. If this does happen, rinse with water.

Do not use other medicated skin products unless your doctor has told you to.

Avoid sexual or intimate contact with others until your lice or scabies infection has cleared up. Avoid sharing hair brushes, combs, hair accessories, hats, clothing, bed linens, and other articles of personal use. Lice and scabies infections are highly contagious.

Malathion side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe stinging, burning, or irritation of your scalp that will not go away.

Less serious side effects may include mild stinging or scalp irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect malathion?

It is not likely that other drugs you take orally or inject will have an effect on topically applied malathion. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More malathion topical resources

• Malathion topical Side Effects (in more detail)
• Malathion topical Use in Pregnancy & Breastfeeding
• Malathion topical Support Group
• 2 Reviews for Malathion - Add your own review/rating

Compare malathion topical with other medications

• Head Lice

Where can I get more information?

• Your pharmacist can provide more information about malathion.

See also: malathion side effects (in more detail)